Reframing chronic wound therapy: from growth factor delivery to regenerative immuno-engineering

Zhiyong Wang; Xuan Zeng; Wenzhao Feng; Yanxin Lu; Pei Wei

PMC · DOI:10.3389/fimmu.2025.1683591·October 22, 2025

Reframing chronic wound therapy: from growth factor delivery to regenerative immuno-engineering

Zhiyong Wang, Xuan Zeng, Wenzhao Feng, Yanxin Lu, Pei Wei

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Abstract

Linked entities

Genes, proteins, chemicals, diseases, species, mutations and cell lines named across the full text — each resolved to its canonical identifier and authoritative record.

Genes9

FGF2 MAPK1 AKT1 TNF VEGFA PTK2B IL4 PIK3CB HPSE

Proteins9

Species2

Mus musculus(house mouse · species)Homo sapiens(human · species)

Chemicals4

heparan sulfate phosphate-buffered saline heparin ROS

Diseases11

infection immunological defect diabetes Inflammation Chronic wounds fibrosis pain metabolic dysregulation immune dysregulation NETs depression

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Taxonomy

TopicsWound Healing and Treatments · Periodontal Regeneration and Treatments · Tissue Engineering and Regenerative Medicine