Cellular and molecular keys to entry: Mechanisms mediating Orthoflavivirus infection of the mosquito midgut

Godfrey Nattoh; Philip M. Armstrong; Doug E. Brackney

PMC · DOI:10.1371/journal.ppat.1013617·October 27, 2025

Cellular and molecular keys to entry: Mechanisms mediating Orthoflavivirus infection of the mosquito midgut

Godfrey Nattoh, Philip M. Armstrong, Doug E. Brackney

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Abstract

Linked entities

Genes, proteins, chemicals, diseases, species, mutations and cell lines named across the full text — each resolved to its canonical identifier and authoritative record.

Genes14

PHB1 CD209 VLDLR CLDN1 SCARB1 MRC1 CD44 LDLR FOXM1 CLEC5A IVNS1ABP CLEC4M CTSL CD300A

Proteins14

Species15

Zika virus(no rank)West Nile virus(no rank)Eastern equine encephalitis virus(no rank)Semliki Forest virus(no rank)Orthohepacivirus(genus)Homo sapiens(human · species)Venezuelan equine encephalitis virus(no rank)Japanese encephalitis virus(no rank)Dengue virus(no rank)Wolbachia pipientis(species)Western equine encephalitis virus(no rank)Sindbis virus(no rank)Yellow fever virus(no rank)hepatitis C virus Aedes aegypti(yellow fever mosquito · species)

Cell lines2

C6/36— Aedes albopictus (Asian tiger mosquito) · Spontaneously immortalized cell line EC-like-2— Homo sapiens (Human) · Human papillomavirus-related cervical squamous cell carcinoma · Cancer cell line

Chemicals3

H2O2 heparan sulfate CFP

Diseases3

viral infection midgut infection infected

Figures2

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Taxonomy

TopicsMosquito-borne diseases and control · Insect symbiosis and bacterial influences · Invertebrate Immune Response Mechanisms