# Cellular and molecular keys to entry: Mechanisms mediating Orthoflavivirus infection of the mosquito midgut

**Authors:** Godfrey Nattoh, Philip M. Armstrong, Doug E. Brackney

PMC · DOI: 10.1371/journal.ppat.1013617 · 2025-10-27

## Full-text entities

- **Genes:** PHB1 (prohibitin 1) [NCBI Gene 5245] {aka BAP32, HEL-215, HEL-S-54e, PHB}, CD209 (CD209 molecule) [NCBI Gene 30835] {aka CDSIGN, CLEC4L, DC-SIGN, DC-SIGN1, hDC-SIGN}, VLDLR (very low density lipoprotein receptor) [NCBI Gene 7436] {aka CAMRQ1, CARMQ1, CHRMQ1, VLDL-R, VLDLRCH}, CLDN1 (claudin 1) [NCBI Gene 9076] {aka CLD1, ILVASC, SEMP1}, SCARB1 (scavenger receptor class B member 1) [NCBI Gene 949] {aka CD36L1, CLA-1, CLA1, HDLCQ6, HDLQTL6, SR-BI}, MRC1 (mannose receptor C-type 1) [NCBI Gene 4360] {aka CD206, CLEC13D, CLEC13DL, MMR, MRC1L1, bA541I19.1}, CD44 (CD44 molecule (IN blood group)) [NCBI Gene 960] {aka CDW44, CSPG8, ECM-III, ECMR-III, H-CAM, HCELL}, LDLR (low density lipoprotein receptor) [NCBI Gene 3949] {aka LDLCQ2}, FOXM1 (forkhead box M1) [NCBI Gene 2305] {aka FKHL16, FOXM1A, FOXM1B, FOXM1C, HFH-11, HFH11}, CLEC5A (C-type lectin domain containing 5A) [NCBI Gene 23601] {aka CLECSF5, MDL-1, MDL1}, IVNS1ABP (influenza virus NS1A binding protein) [NCBI Gene 10625] {aka ARA3, FLARA3, HSPC068, IMD70, KLHL39, ND1}, CLEC4M (C-type lectin domain family 4 member M) [NCBI Gene 10332] {aka CD209L, CD209L1, CD299, DC-SIGN2, DC-SIGNR, DCSIGNR}, CTSL (cathepsin L) [NCBI Gene 1514] {aka CATL, CTSL1, MEP}, CD300A (CD300a molecule) [NCBI Gene 11314] {aka CLM-8, CMRF-35-H9, CMRF-35H, CMRF35-H, CMRF35-H9, CMRF35H}
- **Diseases:** viral infection (MESH:D014777), midgut infection (MESH:C562456), infected (MESH:D007239)
- **Chemicals:** H2O2 (MESH:D006861), heparan sulfate (MESH:D006497), CFP (-)
- **Species:** Zika virus (no rank) [taxon 64320], West Nile virus (no rank) [taxon 11082], Eastern equine encephalitis virus (no rank) [taxon 11021], Semliki Forest virus (no rank) [taxon 11033], Orthohepacivirus (genus) [taxon 11102], Homo sapiens (human, species) [taxon 9606], Venezuelan equine encephalitis virus (no rank) [taxon 11036], Japanese encephalitis virus (no rank) [taxon 11072], Dengue virus (no rank) [taxon 12637], Wolbachia pipientis (species) [taxon 955], Western equine encephalitis virus (no rank) [taxon 11039], Sindbis virus (no rank) [taxon 11034], Yellow fever virus (no rank) [taxon 11089], hepatitis C virus [taxon 11103], Aedes aegypti (yellow fever mosquito, species) [taxon 7159]
- **Cell lines:** C6/36 — Aedes albopictus (Asian tiger mosquito), Spontaneously immortalized cell line (CVCL_Z230), EC-like-2 — Homo sapiens (Human), Human papillomavirus-related cervical squamous cell carcinoma, Cancer cell line (CVCL_WU75)

## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12558446/full.md

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Source: https://tomesphere.com/paper/PMC12558446