A Rare Case of Systemic Amyloidosis Involving the Thyroid in a Young Patient
Oliwia Julia Kasprzak, Kamila Stępińska, Kaja Kiedrowska, Tomasz Błaszkowski, Aleksandra Kudrymska, Sylwia Sikora, Maciej Miernik, Maciej Romanowski
TL;DR
A 28-year-old man with a rare thyroid condition called amyloidosis was diagnosed after a biopsy failed to identify the cause of his symptoms.
Contribution
The paper presents a rare clinical case of systemic amyloidosis involving the thyroid in a young patient.
Findings
Thyroid amyloidosis was confirmed through histopathological examination after a biopsy failed to identify the cause.
The patient exhibited symptoms like neck enlargement, voice alteration, and weight loss.
The case highlights the difficulty in diagnosing benign thyroid enlargement caused by amyloid deposits.
Abstract
Thyroid amyloidosis is a rare condition associated with thyroid pathologies such as medullary carcinoma, papillary carcinoma, amyloid goitre, and benign lesions, with a clinically palpable goitre being exceptionally uncommon. As a result, many cases of benign thyroid enlargement caused by amyloid deposits remain undiagnosed. A 28-year-old male patient noticed progressive neck circumference enlargement, voice alteration, decreased appetite, weight loss, dysphagia, fever, and night sweats. Fine-needle aspiration biopsy of the thyroid gland did not reveal the cause of the goitre. A total thyroidectomy was performed. Histopathological examination confirmed advanced thyroid amyloidosis.
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Taxonomy
TopicsAmyloidosis: Diagnosis, Treatment, Outcomes · Parathyroid Disorders and Treatments · Dermatological and Skeletal Disorders