# A Rare Case of Systemic Amyloidosis Involving the Thyroid in a Young Patient

## TL;DR

A 28-year-old man with a rare thyroid condition called amyloidosis was diagnosed after a biopsy failed to identify the cause of his symptoms.

## Contribution

The paper presents a rare clinical case of systemic amyloidosis involving the thyroid in a young patient.

## Key findings

- Thyroid amyloidosis was confirmed through histopathological examination after a biopsy failed to identify the cause.
- The patient exhibited symptoms like neck enlargement, voice alteration, and weight loss.
- The case highlights the difficulty in diagnosing benign thyroid enlargement caused by amyloid deposits.

## Abstract

Thyroid amyloidosis is a rare condition associated with thyroid pathologies such as medullary carcinoma, papillary carcinoma, amyloid goitre, and benign lesions, with a clinically palpable goitre being exceptionally uncommon. As a result, many cases of benign thyroid enlargement caused by amyloid deposits remain undiagnosed. A 28-year-old male patient noticed progressive neck circumference enlargement, voice alteration, decreased appetite, weight loss, dysphagia, fever, and night sweats. Fine-needle aspiration biopsy of the thyroid gland did not reveal the cause of the goitre. A total thyroidectomy was performed. Histopathological examination confirmed advanced thyroid amyloidosis.