Native Collagen for Surgical Wound and Scar Prevention—A Six-Case Clinical Series

TL;DR

This study explores using native collagen to reduce scarring after plastic surgery, showing promising results in six patients.

Contribution

The study introduces native collagen as a potential new method for improving wound healing and reducing scar formation.

Findings

Patients reported reduced scar tightness, pruritus, and stiffness after collagen injections.

Antera 3D imaging showed decreased vascular and pigment indices and reduced surface elevation.

No adverse effects like atrophy or infection were observed during follow-up.

Abstract

Background: Excessive scarring remains a frequent complication in plastic surgery, yet standardized preventive strategies are lacking. Type I collagen-based biomaterials may support regenerative processes and improve scar outcomes. Methods: This case series includes six female patients (ages 24–52) undergoing wound management after trauma and procedures including blepharoplasty, abdominoplasty, and revision mammaplasty. Native collagen type I (7% or 15%) was injected along wound margins or into hypertrophic scars at 3–4 week intervals. Outcomes were assessed through patient-reported symptoms and Antera 3D imaging (vascularity, pigmentation, surface topography). Results: Patients reported reduced tightness, pruritus, and scar stiffness after initial sessions. Antera 3D imaging showed decreased vascular and pigment indices, and a reduction in surface elevation over follow-up (up to 14 months). No adverse effects such as atrophy or infection were observed. Conclusions: Native type I collagen was well tolerated and may be a useful adjunct for wound healing and scar modulation following plastic surgery.

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