# Native Collagen for Surgical Wound and Scar Prevention—A Six-Case Clinical Series

## TL;DR

This study explores using native collagen to reduce scarring after plastic surgery, showing promising results in six patients.

## Contribution

The study introduces native collagen as a potential new method for improving wound healing and reducing scar formation.

## Key findings

- Patients reported reduced scar tightness, pruritus, and stiffness after collagen injections.
- Antera 3D imaging showed decreased vascular and pigment indices and reduced surface elevation.
- No adverse effects like atrophy or infection were observed during follow-up.

## Abstract

Background: Excessive scarring remains a frequent complication in plastic surgery, yet standardized preventive strategies are lacking. Type I collagen-based biomaterials may support regenerative processes and improve scar outcomes. Methods: This case series includes six female patients (ages 24–52) undergoing wound management after trauma and procedures including blepharoplasty, abdominoplasty, and revision mammaplasty. Native collagen type I (7% or 15%) was injected along wound margins or into hypertrophic scars at 3–4 week intervals. Outcomes were assessed through patient-reported symptoms and Antera 3D imaging (vascularity, pigmentation, surface topography). Results: Patients reported reduced tightness, pruritus, and scar stiffness after initial sessions. Antera 3D imaging showed decreased vascular and pigment indices, and a reduction in surface elevation over follow-up (up to 14 months). No adverse effects such as atrophy or infection were observed. Conclusions: Native type I collagen was well tolerated and may be a useful adjunct for wound healing and scar modulation following plastic surgery.