A Decade of Progress: Review of the Synthesis of Dibenzo[b,f]oxepines
Gabriel Pereira da Costa, Bruna Rafaella Schneider, Angelita Manke Barcellos, Liane Krolow Soares, Rafael Centurião Brinkerhoff, Fernanda Piecha Ludwig, Alex Fabiani Claro Flores
TL;DR
This review summarizes progress in making dibenzo[b,f]oxepines, which are important for medicine and materials, over the past ten years.
Contribution
The paper provides a comprehensive overview of recent synthetic strategies and emerging trends in dibenzo[b,f]oxepine synthesis.
Findings
Efficient methods like cross-coupling and cyclizations are highlighted for synthesizing dibenzo[b,f]oxepines.
Sustainability, selectivity, and structural diversity are identified as key areas of focus in recent research.
Emerging trends include the development of greener and more optimized synthetic approaches.
Abstract
This review article highlights the significant advances in the synthesis of dibenzo[b,f]oxepines over the past decade. Dibenzo[b,f]oxepines, important heterocyclic compounds, have attracted increasing interest due to their wide‐ranging applications in medicinal chemistry and materials applications. The review addresses traditional approaches and recent developments, highlighting efficient synthetic strategies such as cross‐coupling reactions, intramolecular cyclizations, and molecular diversification strategies. Additionally, the efficiency, selectivity, and sustainability of these methods are discussed. Emerging trends and future challenges in the synthesis of dibenzo[b,f]oxepines are also explored, including the search for more sustainable methods, the expansion of structural diversity, and the optimizing reaction conditions. This review provides a comprehensive overview of recent…
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Taxonomy
TopicsCatalytic C–H Functionalization Methods · Chemical synthesis and alkaloids · Phenothiazines and Benzothiazines Synthesis and Activities