# A Decade of Progress: Review of the Synthesis of Dibenzo[b,f]oxepines

## TL;DR

This review summarizes progress in making dibenzo[b,f]oxepines, which are important for medicine and materials, over the past ten years.

## Contribution

The paper provides a comprehensive overview of recent synthetic strategies and emerging trends in dibenzo[b,f]oxepine synthesis.

## Key findings

- Efficient methods like cross-coupling and cyclizations are highlighted for synthesizing dibenzo[b,f]oxepines.
- Sustainability, selectivity, and structural diversity are identified as key areas of focus in recent research.
- Emerging trends include the development of greener and more optimized synthetic approaches.

## Abstract

This review article highlights the significant advances in the synthesis of dibenzo[b,f]oxepines over the past decade. Dibenzo[b,f]oxepines, important heterocyclic compounds, have attracted increasing interest due to their wide‐ranging applications in medicinal chemistry and materials applications. The review addresses traditional approaches and recent developments, highlighting efficient synthetic strategies such as cross‐coupling reactions, intramolecular cyclizations, and molecular diversification strategies. Additionally, the efficiency, selectivity, and sustainability of these methods are discussed. Emerging trends and future challenges in the synthesis of dibenzo[b,f]oxepines are also explored, including the search for more sustainable methods, the expansion of structural diversity, and the optimizing reaction conditions. This review provides a comprehensive overview of recent advances in this field, providing valuable insights for researchers aiming to develop novel synthetic strategies and applications for dibenzo[b,f]oxepines.

This review summarizes recent advances in dibenzo[b,f]oxepine synthesis, highlighting medicinal and materials applications. It discusses classical and modern methods, including cross‐coupling, intramolecular cyclizations, and diversification strategies, emphasizing efficiency, selectivity, and sustainability. Emerging trends such as greener approaches, structural diversity, and optimized conditions are addressed, providing researchers with valuable insights into innovative synthetic strategies and potential applications.© 2025 WILEY‐VCH GmbH