Urinary Bladder Matrix as a Guide Bone Regeneration Barrier Membrane for Inhibiting Cell Invasion and Promoting Bone Formation
Jie Zhong, Zhaoxin Chen, Yangqian Gu, Yiwen Xu, Wenyue Cheng, Jing Dai, Yang Sun, Siqing Yao, Mengmeng Lu, Jian Zhang
TL;DR
A new bone regeneration membrane made from urinary bladder matrix improves bone growth and prevents unwanted cell invasion in dental implants.
Contribution
A novel urinary bladder matrix-coated membrane enhances GBR performance with better mechanical strength and slower degradation.
Findings
The UBM-SIS membrane showed superior tensile strength and slower degradation than Bio-Gide.
In canine models, UBM-SIS increased bone trabeculae quantity and maturity over 24 weeks.
The membrane resisted fibroblast invasion and promoted osteoblast growth in early stages.
Abstract
Natural resorbable collagen membranes are widely used in guided bone regeneration (GBR) in oral implantology and prosthodontics. However, the rapid degradation and inadequate mechanical properties raise concerns about potentially compromising the ultimate bone regeneration efficacy. In this study, we developed a novel GBR membrane by coating a urinary bladder matrix (UBM) onto small intestinal submucosa (SIS), a commonly used acellular material, to improve the cell-barrier and bone-regeneration performances. The results showed that the UBM-SIS membrane exhibited superior tensile strength, high compliance, and slower degradation rate compared to a commercial Bio-Gide membrane, thereby enhancing the support and maintenance properties. In vitro studies indicated enhanced osteogenic behavior and higher osteogenic cytokine expression in human bone marrow-derived mesenchymal stromal cells…
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Taxonomy
TopicsTissue Engineering and Regenerative Medicine · Electrospun Nanofibers in Biomedical Applications · Urological Disorders and Treatments