New Tirucallane-Type Triterpenes Isolated from Commiphora oddurensis from Ethiopia with Anticancer Activity
Taame G. Seyoum, Zhenming Du, Siming Wang, Wen Lu, Qiyue Mao, Xiaoxiao Yang, Aman Dekebo, Ermias Dagne, Paulos Yohannes, Binghe Wang
TL;DR
Scientists discovered three new compounds from an Ethiopian plant that show strong anticancer effects, especially against HeLa cells.
Contribution
The discovery of three new tirucallane-type triterpenes with potent anticancer activity from Commiphora oddurensis.
Findings
Three new tirucallane-type triterpenes were isolated from Commiphora oddurensis.
All three compounds showed anticancer activity against HeLa cells.
Oddurensinoid H was the most potent with an IC50 of 0.017 mg/mL.
Abstract
Three new tirucallane-type triterpenes, tirucalla-7,24-diene-1β,3β-diol (oddurensinoid B), tirucalla-7-ene-1β,3β,25-triol (oddurensinoid H), and tirucalla-7, 24-diene-3β-ol-1-O-β-d-glucopyranoside (oddurensinoid K), were isolated from the resin of Commiphora oddurensis harvested from Ethiopia, Africa. Their structures were elucidated by one-dimensional (1D) NMR, two-dimensional (2D) NMR, and high-resolution mass spectrometry (HRMS). All three compounds were tested for their anticancer activity against HeLa cell lines. They all exhibit anticancer activity, with oddurensinoid H the most potent with IC50 of 0.017 mg/mL (36.9 μM).
Genes, proteins, chemicals, diseases, species, mutations and cell lines named across the full text — each resolved to its canonical identifier and authoritative record.
Click any figure to enlarge with its caption.
Figure 1
Figure 2
Figure 3
Figure 4
Figure 5
Figure 6
Figure 7
Figure 8
Figure 9
Figure 10Peer Reviews
No public reviews on file for this paper yet. If you reviewed it on a platform where reviews are public (OpenReview, ICLR, NeurIPS, ICML), you can paste yours below so the community can read it here.
Videos
No videos yet. Explain this paper in a talk, walkthrough, or lecture? Add one.
Taxonomy
TopicsPharmacological Effects of Medicinal Plants · Ethnobotanical and Medicinal Plants Studies