# New Tirucallane-Type Triterpenes Isolated from Commiphora oddurensis from Ethiopia with Anticancer Activity

## TL;DR

Scientists discovered three new compounds from an Ethiopian plant that show strong anticancer effects, especially against HeLa cells.

## Contribution

The discovery of three new tirucallane-type triterpenes with potent anticancer activity from Commiphora oddurensis.

## Key findings

- Three new tirucallane-type triterpenes were isolated from Commiphora oddurensis.
- All three compounds showed anticancer activity against HeLa cells.
- Oddurensinoid H was the most potent with an IC50 of 0.017 mg/mL.

## Abstract

Three new tirucallane-type triterpenes, tirucalla-7,24-diene-1β,3β-diol
(oddurensinoid B), tirucalla-7-ene-1β,3β,25-triol
(oddurensinoid H), and tirucalla-7, 24-diene-3β-ol-1-O-β-d-glucopyranoside (oddurensinoid K), were isolated from the resin of Commiphora
oddurensis harvested from Ethiopia, Africa. Their
structures were elucidated by one-dimensional (1D) NMR, two-dimensional
(2D) NMR, and high-resolution mass spectrometry (HRMS). All three
compounds were tested for their anticancer activity against HeLa cell
lines. They all exhibit anticancer activity, with oddurensinoid H the most potent with IC50 of 0.017 mg/mL (36.9
μM).