Kidney transplantation between identical twins with APOL1 homozygote risk alleles – a case report
Sean Lei, Abhirami Shankar, Supreet Sethi, Erik L. Lum
TL;DR
A case report describes successful kidney transplantation between identical twins with a high-risk APOL1 gene variant.
Contribution
Demonstrates successful transplantation outcomes despite high-risk APOL1 genotype in identical twins.
Findings
Identical twins with APOL1 homozygote risk alleles underwent successful living kidney transplantation.
Short-term outcomes for both donor and recipient were excellent.
Abstract
Kidney transplantation is the optimal therapy for individuals with end-stage kidney disease. Recent studies suggest a negative impact of high-risk Apolipoprotein L1 genotypes on outcomes for both living kidney donors and kidney transplant recipients. In this case, we describe a pair of identical twins with a high-risk APOL1 genotype who underwent successful living kidney transplantation with excellent short-term outcomes.
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Taxonomy
TopicsRenal Diseases and Glomerulopathies · Chronic Lymphocytic Leukemia Research · Chronic Kidney Disease and Diabetes