Dietary Supplementation with Probiotics Alleviates Intestinal Injury in LPS-Challenged Piglets
Di Zhao, Junmei Zhang, Dan Yi, Tao Wu, Maoxin Dou, Lei Wang, Yongqing Hou
TL;DR
Adding probiotics to piglets' diets helps protect their intestines from LPS-induced damage and improves immune responses.
Contribution
The study demonstrates that specific probiotics can mitigate LPS-induced intestinal injury in piglets through immune modulation.
Findings
Probiotic supplementation reduced LPS-induced intestinal damage and improved barrier function.
Probiotics modulated immune responses by affecting NF-κB, IL-4, IL-6, IL-10, and other gene expressions.
Both Lactobacillus and Bacillus probiotics showed health-promoting effects in LPS-challenged piglets.
Abstract
This study aimed to assess whether dietary supplementation with probiotics could alleviate intestinal injury in lipopolysaccharide (LPS)-challenged piglets. Healthy weaned piglets were randomly allocated to four individual groups (n = 6): (1) a control group; (2) an LPS group; (3) an LPS + Lactobacillus group; and (4) an LPS + Bacillus group. The control and LPS groups received a basal diet, while the probiotic groups were provided with the same basal diet supplemented with 6 × 106 cfu/g of Lactobacillus casei (L. casei) or a combination of Bacillus subtilis (B. subtilis) and Bacillus licheniformis (B. licheniformis) at a dosage of 3 × 106 cfu/g, respectively. On day 31 of the trial, overnight-fasted piglets were killed following the administration of either LPS or 0.9% NaCl solution. Blood samples and intestinal tissues were obtained for further analysis several hours later. The…
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Taxonomy
TopicsProbiotics and Fermented Foods · Gut microbiota and health · Animal Nutrition and Physiology