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Silas A. Buck, Samuel J. Mabry, Tenzin Kunkhyen, Zilu Yang, Sophie A. Rubin, Jinting Yang, Claire E. J. Cheetham, Zachary Freyberg
TL;DR
The paper explores how dVGLUT affects dopamine neuron mitochondria in aging and Parkinson's disease, with differences between sexes.
Contribution
The study identifies dVGLUT as a mediator of sex differences in mitochondrial function in dopamine neurons.
Findings
dVGLUT mediates sex differences in dopamine neuron mitochondrial function during aging.
Sex differences in mitochondrial function are also observed in a Parkinson's disease model.
Abstract
Cover legend: The cover image is based on the article dVGLUT Is a Mediator of Sex Differences in Dopamine Neuron Mitochondrial Function Across Aging and in a Parkinson's Disease Model by Silas A. Buck et al., https://doi.org/10.1111/acel.70096.
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Taxonomy
TopicsParkinson's Disease Mechanisms and Treatments · Nuclear Receptors and Signaling · Genetic Neurodegenerative Diseases