Red-Shifted Glycoporphyrins: Synthesis via Sonogashira Cross-Coupling and Studies on Reactive Oxygen Species Production
Dariusz Baran, Maciej Malinowski
TL;DR
This paper introduces a new method to create glycoporphyrins that absorb longer wavelengths of light and can produce reactive oxygen species for potential use in phototherapy.
Contribution
A novel Sonogashira-based method for conjugating sugars with porphyrins, enabling red-shifted absorption and ROS generation.
Findings
The new method successfully conjugates sugar units with porphyrins via C–C bonds.
The resulting glycoporphyrins show a bathochromic shift in absorption maxima.
They generate reactive oxygen species under 690–740 nm visible light.
Abstract
Glycoporphyrins are in the spotlight as third-generation photosensitizers. Herein, we present a new Sonogashira-based methodology toward C–C-bonded, diverse carbohydrate–porphyrin hybrids. The sugar unit is for the first time effectively conjugated with a porphyrin system, resulting in a bathochromic shift of absorption maxima. The products generate reactive oxygen species with the use of 690–740 nm visible light lamps, making them promising photosensitizers in phototherapies.
Genes, proteins, chemicals, diseases, species, mutations and cell lines named across the full text — each resolved to its canonical identifier and authoritative record.
Click any figure to enlarge with its caption.
Figure 1
Figure 2
Figure 3
Figure 4
Figure 5
Figure 6
Figure 7
Figure 8
Figure 9
Figure 10
Figure 11
Figure 12Peer Reviews
No public reviews on file for this paper yet. If you reviewed it on a platform where reviews are public (OpenReview, ICLR, NeurIPS, ICML), you can paste yours below so the community can read it here.
Videos
No videos yet. Explain this paper in a talk, walkthrough, or lecture? Add one.
Taxonomy
TopicsPorphyrin and Phthalocyanine Chemistry · Photodynamic Therapy Research Studies · Nanoplatforms for cancer theranostics