# Red-Shifted Glycoporphyrins: Synthesis via Sonogashira Cross-Coupling and Studies on Reactive Oxygen Species Production

## TL;DR

This paper introduces a new method to create glycoporphyrins that absorb longer wavelengths of light and can produce reactive oxygen species for potential use in phototherapy.

## Contribution

A novel Sonogashira-based method for conjugating sugars with porphyrins, enabling red-shifted absorption and ROS generation.

## Key findings

- The new method successfully conjugates sugar units with porphyrins via C–C bonds.
- The resulting glycoporphyrins show a bathochromic shift in absorption maxima.
- They generate reactive oxygen species under 690–740 nm visible light.

## Abstract

Glycoporphyrins are
in the spotlight as third-generation
photosensitizers.
Herein, we present a new Sonogashira-based methodology toward C–C-bonded,
diverse carbohydrate–porphyrin hybrids. The sugar unit is for
the first time effectively conjugated with a porphyrin system, resulting
in a bathochromic shift of absorption maxima. The products generate
reactive oxygen species with the use of 690–740 nm visible
light lamps, making them promising photosensitizers in phototherapies.