Learning From a Missed Diagnosis: Complete Agenesis of the Corpus Callosum With Benign Hydrocephalus

J. E. Samaranayake; S. M. Kankanamge; P. Pirakash; U. A. Liyanage; Y. Mathangasinghe; D. G. Gonsalvez; N. Gunasekera

PMC · DOI:10.1002/ccr3.70693·July 29, 2025

Learning From a Missed Diagnosis: Complete Agenesis of the Corpus Callosum With Benign Hydrocephalus

J. E. Samaranayake, S. M. Kankanamge, P. Pirakash, U. A. Liyanage, Y. Mathangasinghe, D. G. Gonsalvez, N. Gunasekera

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TL;DR

The paper discusses managing benign hydrocephalus in complete agenesis of the corpus callosum through regular monitoring rather than surgery.

Contribution

It emphasizes the importance of follow-up and non-interventional management in cases without cerebrospinal fluid obstruction.

Findings

01

Ventriculomegaly without fluid obstruction often does not require surgery.

02

Regular follow-up is essential to detect neurological decline or raised intracranial pressure.

03

Advanced imaging and surgical management should be considered if deterioration occurs.

Abstract

In agenesis of the corpus callosum, ventriculomegaly without evidence of cerebrospinal fluid obstruction often requires no surgical intervention. Regular follow‐up every 3–6 months, then annually, is essential to monitor for signs of raised intracranial pressure or neurological decline—prompting advanced imaging and consideration of surgical management if deterioration occurs.

Linked entities

Genes, proteins, chemicals, diseases, species, mutations and cell lines named across the full text — each resolved to its canonical identifier and authoritative record.

Genes1

CRP

Proteins1

Species1

Homo sapiens(human · species)

Chemicals4

alcohol sodium paracetamol potassium

Diseases48

agenesis of the corpus callosum intellectual disabilities foetal alcohol syndrome upper respiratory tract infection head trauma papilledema pain genetic abnormalities respiratory symptoms chromosomal anomalies interhemispheric cyst seizures AgCC malformations subdural hematomas dilation of the teratogens brain tumors congenital malformations deficits fever visual field defects Benign Hydrocephalus gait disturbances perinatal infections congenital infections developmental delay loss of consciousness limb deformities rhinitis headache meningism psychiatric genital abnormalities cerebral oedema developmental abnormalities central nervous system malformations skeletal anomalies intracranial hemorrhage colpocephaly visual or auditory impairments raised intracranial pressure cerebellar and brainstem abnormalities craniofacial dysmorphism cognitive decline neurological deterioration congenital anomalies nasal congestion

Figures3

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Taxonomy

TopicsFetal and Pediatric Neurological Disorders · Cerebrospinal fluid and hydrocephalus · Neonatal and fetal brain pathology