# Learning From a Missed Diagnosis: Complete Agenesis of the Corpus Callosum With Benign Hydrocephalus

**Authors:** J. E. Samaranayake, S. M. Kankanamge, P. Pirakash, U. A. Liyanage, Y. Mathangasinghe, D. G. Gonsalvez, N. Gunasekera

PMC · DOI: 10.1002/ccr3.70693 · 2025-07-29

## TL;DR

The paper discusses managing benign hydrocephalus in complete agenesis of the corpus callosum through regular monitoring rather than surgery.

## Contribution

It emphasizes the importance of follow-up and non-interventional management in cases without cerebrospinal fluid obstruction.

## Key findings

- Ventriculomegaly without fluid obstruction often does not require surgery.
- Regular follow-up is essential to detect neurological decline or raised intracranial pressure.
- Advanced imaging and surgical management should be considered if deterioration occurs.

## Abstract

In agenesis of the corpus callosum, ventriculomegaly without evidence of cerebrospinal fluid obstruction often requires no surgical intervention. Regular follow‐up every 3–6 months, then annually, is essential to monitor for signs of raised intracranial pressure or neurological decline—prompting advanced imaging and consideration of surgical management if deterioration occurs.

## Linked entities

- **Diseases:** agenesis of the corpus callosum (MONDO:0009022)

## Full-text entities

- **Genes:** CRP (C-reactive protein) [NCBI Gene 1401] {aka PTX1}
- **Diseases:** intellectual disabilities (MESH:D008607), foetal alcohol syndrome (MESH:D000437), upper respiratory tract infection (MESH:D012141), head trauma (MESH:D006259), papilledema (MESH:D010211), pain (MESH:D010146), genetic abnormalities (MESH:D030342), respiratory symptoms (MESH:D012818), chromosomal anomalies (MESH:D002869), interhemispheric cyst (MESH:D003560), seizures (MESH:D012640), AgCC (MESH:D061085), malformations (MESH:C564254), subdural hematomas (MESH:D006408), dilation of the (MESH:D002311), teratogens (MESH:C535542), brain tumors (MESH:D001932), congenital malformations (OMIM:163000), deficits (MESH:D009461), fever (MESH:D005334), visual field defects (MESH:D005128), Benign Hydrocephalus (MESH:D006849), gait disturbances (MESH:D020233), perinatal infections (MESH:D003586), congenital infections (MESH:D007239), developmental delay (MESH:D002658), loss of consciousness (MESH:D014474), limb deformities (MESH:D017880), rhinitis (MESH:D012220), headache (MESH:D006261), meningism (MESH:D008580), psychiatric (MESH:D001523), genital abnormalities (MESH:D014564), cerebral oedema (MESH:D001929), developmental abnormalities (MESH:D006130), central nervous system malformations (MESH:D020785), skeletal anomalies (MESH:C535534), intracranial hemorrhage (MESH:D020300), colpocephaly (MESH:C535973), visual or auditory impairments (MESH:D014786), raised intracranial pressure (MESH:D019586), cerebellar and brainstem abnormalities (MESH:D002526), craniofacial dysmorphism (MESH:C537512), cognitive decline (MESH:D003072), neurological deterioration (MESH:D009422), congenital anomalies (MESH:D000013), nasal congestion (MESH:D009668)
- **Chemicals:** alcohol (MESH:D000438), sodium (MESH:D012964), paracetamol (MESH:D000082), potassium (MESH:D011188)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Figures

3 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12305111/full.md

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Source: https://tomesphere.com/paper/PMC12305111