Case Report: The Parkes-Weber syndrome in the patient who underwent coronary surgery

Nemanja Milosevic; Bogdan Okiljevic; Slobodan Micovic; Milovan Bojic; Igor Zivkovic

PMC · DOI:10.3389/fcvm.2025.1479811·July 15, 2025

Case Report: The Parkes-Weber syndrome in the patient who underwent coronary surgery

Nemanja Milosevic, Bogdan Okiljevic, Slobodan Micovic, Milovan Bojic, Igor Zivkovic

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TL;DR

This case report describes a 73-year-old man with Parkes-Weber Syndrome and coronary disease who underwent heart surgery.

Contribution

The report highlights the importance of identifying Parkes-Weber Syndrome in patients with heart disease to avoid complications.

Findings

01

Parkes-Weber Syndrome can coexist with coronary artery disease and impact heart function.

02

Surgical management is possible in patients with PWS and borderline heart function.

03

Early diagnosis of PWS is crucial to prevent high-output heart failure.

Abstract

Parkes-Weber Syndrome is a rare congenital vascular abnormality characterized by aneurismatic illness of blood arteries in the afflicted limb, as well as hypertrophy, ulceration, ischemia, and high-output heart failure. Imaging investigations are required to provide a diagnosis, with contrast arteriography being the gold standard. The majority of treatment options are endovascular, with surgical excision for arteriovenous malformations and limb amputation as alternatives. We describe a 73-year-old male patient with mainly asymptomatic PWS, coronary disease, and borderline EF (45%) who had CABG surgery. In individuals with established CAD and other cardiac disorders, it is critical to identify additional diseases or syndromes that might have a compounding effect on the heart, such as PWS and high-output heart failure.

Linked entities

Genes, proteins, chemicals, diseases, species, mutations and cell lines named across the full text — each resolved to its canonical identifier and authoritative record.

Genes1

RASA1

Proteins1

Species1

Homo sapiens(human · species)

Chemicals11

bisoprolol trimetazidine ramipril dapagliflozin KCl isosorbide mononitrate clopidogrel acetylsalicylic acid rosuvastatin furosemide torasemide

Diseases59

Parkes-Weber Syndrome coronary artery disease high-output heart failure thyrotoxicosis Elevated cardiac output angina akinetic three-vessel disease coronary disease fluid retention acute coronary syndrome arterio-venous malformation hypercapnia limb swelling losing consciousness cardiac disorders tachycardia hyperthyroidism arteriovenous fistula hypertrophy cardiovascular disease ischemic heart disease capillary, venous, lymphatic, and arteriovenous malformation vascular malformations anemia aneurysm of abdominal aorta high anginal pain sepsis congenital disease Paget's disease aneurysm breathlessness pleural effusion arterial ischemia MR Heart failure PWS myocardial damage congenital vascular abnormality atherosclerotic AV fistula embolization aneurismatic illness venous ulcerations stenosis fatigue High-output pulmonary rales ischemic dyslipidemia hypertension congenital vascular anomalies Beriberi heart disease ulceration steal syndrome AVM myocardial infarction obesity

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Taxonomy

TopicsCardiac tumors and thrombi · Congenital Heart Disease Studies · Vascular anomalies and interventions