# Case Report: The Parkes-Weber syndrome in the patient who underwent coronary surgery

**Authors:** Nemanja Milosevic, Bogdan Okiljevic, Slobodan Micovic, Milovan Bojic, Igor Zivkovic

PMC · DOI: 10.3389/fcvm.2025.1479811 · 2025-07-15

## TL;DR

This case report describes a 73-year-old man with Parkes-Weber Syndrome and coronary disease who underwent heart surgery.

## Contribution

The report highlights the importance of identifying Parkes-Weber Syndrome in patients with heart disease to avoid complications.

## Key findings

- Parkes-Weber Syndrome can coexist with coronary artery disease and impact heart function.
- Surgical management is possible in patients with PWS and borderline heart function.
- Early diagnosis of PWS is crucial to prevent high-output heart failure.

## Abstract

Parkes-Weber Syndrome is a rare congenital vascular abnormality characterized by aneurismatic illness of blood arteries in the afflicted limb, as well as hypertrophy, ulceration, ischemia, and high-output heart failure. Imaging investigations are required to provide a diagnosis, with contrast arteriography being the gold standard. The majority of treatment options are endovascular, with surgical excision for arteriovenous malformations and limb amputation as alternatives. We describe a 73-year-old male patient with mainly asymptomatic PWS, coronary disease, and borderline EF (45%) who had CABG surgery. In individuals with established CAD and other cardiac disorders, it is critical to identify additional diseases or syndromes that might have a compounding effect on the heart, such as PWS and high-output heart failure.

## Linked entities

- **Diseases:** Parkes-Weber Syndrome (MONDO:0700325), coronary artery disease (MONDO:0005010), high-output heart failure (MONDO:0005253)

## Full-text entities

- **Genes:** RASA1 (RAS p21 protein activator 1) [NCBI Gene 5921] {aka CM-AVM, CMAVM, CMAVM1, GAP, PKWS, RASA}
- **Diseases:** thyrotoxicosis (MESH:C566386), Elevated cardiac output (MESH:D002303), angina (MESH:D000787), akinetic (MESH:D018476), three-vessel disease (MESH:C536223), coronary disease (MESH:D003327), fluid retention (MESH:D016055), acute coronary syndrome (MESH:D054058), arterio-venous malformation (MESH:D001159), hypercapnia (MESH:D006935), limb swelling (MESH:D004487), losing consciousness (MESH:D003244), cardiac disorders (MESH:D006331), tachycardia (MESH:D013610), hyperthyroidism (MESH:D006980), arteriovenous fistula (MESH:D001164), hypertrophy (MESH:D006984), cardiovascular disease (MESH:D002318), ischemic heart disease (MESH:D017202), capillary, venous, lymphatic, and arteriovenous malformation (MESH:C564254), vascular malformations (MESH:D054079), anemia (MESH:D000740), aneurysm of abdominal aorta (MESH:D017544), high (MESH:D008228), anginal pain (MESH:D010146), sepsis (MESH:D018805), congenital disease (MESH:D030342), Paget's disease (MESH:C537701), aneurysm (MESH:D000783), breathlessness (MESH:D004417), pleural effusion (MESH:D010996), arterial ischemia (MESH:D007511), MR (MESH:D008944), Heart failure (MESH:D006333), PWS (MESH:D013341), myocardial damage (MESH:D009202), congenital vascular abnormality (MESH:D000013), atherosclerotic (MESH:D050197), AV fistula (MESH:D054537), embolization (MESH:D004617), aneurismatic illness (MESH:D002908), venous ulcerations (MESH:D014647), PWS (MESH:D011218), stenosis (MESH:D003251), fatigue (MESH:D005221), High-output (MESH:D016534), pulmonary rales (MESH:D012135), ischemic (MESH:D002545), dyslipidemia (MESH:D050171), hypertension (MESH:D006973), congenital vascular anomalies (MESH:D020785), Beriberi heart disease (MESH:D001602), ulceration (MESH:D014456), steal syndrome (MESH:D013349), AVM (MESH:D001165), myocardial infarction (MESH:D009203), obesity (MESH:D009765), coronary artery disease (MESH:D003324)
- **Chemicals:** bisoprolol (MESH:D017298), trimetazidine (MESH:D014292), ramipril (MESH:D017257), dapagliflozin (MESH:C529054), KCl (MESH:D011189), isosorbide mononitrate (MESH:C030397), clopidogrel (MESH:D000077144), acetylsalicylic acid (MESH:D001241), rosuvastatin (MESH:D000068718), furosemide (MESH:D005665), torasemide (MESH:D000077786)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Figures

3 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12303869/full.md

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Source: https://tomesphere.com/paper/PMC12303869