Hypergravity and ERK Inhibition Combined Synergistically Reduce Pathological Tau Phosphorylation in a Neurodegenerative Cell Model
Valerio Mignucci, Ivana Barravecchia, Davide De Luca, Giacomo Siano, Cristina Di Primio, Jack J. W. A. van Loon, Debora Angeloni
TL;DR
Hypergravity combined with ERK inhibition reduces harmful Tau protein changes in a lab model of neurodegeneration.
Contribution
The synergistic effect of hypergravity and ERK inhibition on Tau phosphorylation is newly demonstrated in a neurodegenerative cell model.
Findings
50× g hypergravity combined with PD-0325901 reduced Tau aggregate area in HT22 cells.
The treatment decreased phosphorylation at key Tau residues pS262 and pS396.
Hypergravity may help reduce cytoskeletal damage caused by Tau aggregation.
Abstract
This study evaluates the effects of hypergravity (HG) on a neurodegenerative model in vitro, looking at how HG influences Tau protein aggregation in Mouse Hippocampal Neuronal Cells (HT22) induced by neurofibrillary tangle seeds. Overall, 50× g significantly, synergistically, reduced the Tau aggregate Area when combined with ERK-inhibitor PD-0325901, correlating with decreased phosphorylation at critical residues pS262 and pS396. These findings suggest HG treatments may help mitigate cytoskeletal damage linked to Tau aggregation.
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Taxonomy
TopicsSpaceflight effects on biology · Mitochondrial Function and Pathology · Genetics, Aging, and Longevity in Model Organisms