Clinical and Evolutive Features of Tuberculous Meningitis in an Immunosuppressed Adolescent During the COVID 19 Pandemic
Dalia Dop, Vlad Pădureanu, Rodica Pădureanu, Iulia Rahela Marcu, Suzana Măceș, Anca Emanuela Mușetescu, Ștefan Adrian Niculescu, Carmen Elena Niculescu
TL;DR
This paper discusses the challenges of diagnosing tuberculous meningitis in an immunosuppressed adolescent during the COVID-19 pandemic, emphasizing the importance of early detection for better outcomes.
Contribution
The study highlights the diagnostic difficulties and clinical management of tuberculous meningitis in immunosuppressed children during the pandemic.
Findings
Tuberculous meningitis in immunosuppressed adolescents presents with nonspecific symptoms, delaying diagnosis.
Empirical antituberculosis therapy was initiated before confirmation, leading to a favorable outcome despite a delayed diagnosis.
The case underscores the need for heightened clinical suspicion to avoid diagnostic delays in high-risk patients.
Abstract
Background/Objectives: Tuberculous meningitis is the most severe form of tuberculosis in children, with a high mortality and morbidity rate if it is not diagnosed and treated in a timely manner. The aim of this study is to highlight the challenges associated with establishing a diagnosis of tuberculous meningitis in a child with immunosuppression, given the presence of nonspecific clinical manifestations. Methods: We present the case of a 15-year-old adolescent with systemic lupus erythematosus, on immunosuppressive therapy, who is diagnosed with tuberculous meningoencephalitis presenting the clinical, diagnostic and imaging characteristics, as well as the diagnostic traps and limitations associated with this condition. Antituberculosis therapy was started empirically, because there was no improvement in the clinical status with conventional antibiotic therapy; the diagnosis was…
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Taxonomy
TopicsInfectious Diseases and Tuberculosis · Tuberculosis Research and Epidemiology · Orthopedic Infections and Treatments