Association between Gut Microbiota Composition and Copy Number Variations in Human Genes FAM66D and TAS2R43

TL;DR

This study explores how copy number variations in specific human genes are linked to the composition of gut microbiota.

Contribution

The study identifies specific genes whose copy number variations are associated with gut microbiota composition.

Findings

Copy numbers of 50 genes varied among the cohort, with 7 genes showing a link to gut microbiota.

FAM66D and TAS2R43 CNVs were systematically analyzed for their relationship with gut microbiota.

A potential connection between human genetic variations and gut microbiota composition is hypothesized.

Abstract

The impact of the gut microbiota on human health has attracted increasing attention. However, the factors affecting the gut microbiota need more in-depth research. In this work, we analyzed the impact of the gut microbiota at the genetic levels, mainly gene copy number variations (CNVs). We used Permutational Multivariate Analysis of Variance (PERMANOVA, Adonis) analysis to assess the association between CNVs and the gut microbiota. The results showed that copy numbers of 50 genes varied among the cohort. Among them, the CNVs of 7 genes, including TBC1D3L, OR4C6, NPIPB15, PDPR, USP17L7, FAM66D and TAS2R43, were related to the gut microbiota. In addition, among these genes, we systematically analyzed the relationship between CNVs of FAM66D and TAS2R43 with the gut microbiota. We hypothesize that there exists a certain association between genetic information in the human genome (such as CNVs) and human behavior as well as gut microbiota.

Figures