The role of matrix metalloproteinases in the modulation of aqueous humor in glaucoma patients
Cerbulescu Teodor, Barac Ileana Ramona, Boruga Ovidiu, Sălăvăţ Mădălina Casiana, Leuştean Laurenţiu, Duncă Ştefan Daciana, Calancea Andrei, Barac Andreea Diana
TL;DR
This paper reviews how matrix metalloproteinases affect aqueous humor and intraocular pressure in glaucoma, highlighting their potential as treatment targets.
Contribution
The paper provides a comprehensive review of matrix metalloproteinases' role in aqueous humor dynamics and their therapeutic potential in glaucoma.
Findings
Matrix metalloproteinases influence extracellular matrix remodeling in ocular structures.
Their activity affects aqueous humor outflow and intraocular pressure in glaucoma patients.
These enzymes are proposed as potential therapeutic targets for glaucoma treatment.
Abstract
Matrix metalloproteinases are crucial proteolytic enzymes involved in the degradation and remodeling of the extracellular matrix within the ocular structures. Their expression and activity significantly influence aqueous humor dynamics and intraocular pressure in patients with glaucoma. Elevated intraocular pressure, a significant risk factor for glaucoma, is often associated with disturbed aqueous humor outflow. This review summarizes current findings on the role of matrix metalloproteinases in modulating aqueous humor and their potential as therapeutic targets in the treatment of glaucoma.
Genes, proteins, chemicals, diseases, species, mutations and cell lines named across the full text — each resolved to its canonical identifier and authoritative record.
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Taxonomy
TopicsGlaucoma and retinal disorders · Ocular Surface and Contact Lens · Corneal surgery and disorders