# The role of matrix metalloproteinases in the modulation of aqueous humor in glaucoma patients

## TL;DR

This paper reviews how matrix metalloproteinases affect aqueous humor and intraocular pressure in glaucoma, highlighting their potential as treatment targets.

## Contribution

The paper provides a comprehensive review of matrix metalloproteinases' role in aqueous humor dynamics and their therapeutic potential in glaucoma.

## Key findings

- Matrix metalloproteinases influence extracellular matrix remodeling in ocular structures.
- Their activity affects aqueous humor outflow and intraocular pressure in glaucoma patients.
- These enzymes are proposed as potential therapeutic targets for glaucoma treatment.

## Abstract

Matrix metalloproteinases are crucial proteolytic enzymes involved in the degradation and remodeling of the extracellular matrix within the ocular structures. Their expression and activity significantly influence aqueous humor dynamics and intraocular pressure in patients with glaucoma. Elevated intraocular pressure, a significant risk factor for glaucoma, is often associated with disturbed aqueous humor outflow.

This review summarizes current findings on the role of matrix metalloproteinases in modulating aqueous humor and their potential as therapeutic targets in the treatment of glaucoma.