A Novel CLTC::RPS6KB1 Fusion in a Poorly Differentiated Carcinoma Involving the Lung and Mediastinum
Mitchell Zhao, Nicholas Protopsaltis, Mina Sabet, Shulei Sun, Grace Lin, Farnaz Hasteh, Wei Song
TL;DR
A new gene fusion, CLTC::RPS6KB1, was found in a rare lung and mediastinum cancer with no known molecular drivers.
Contribution
The discovery of a novel CLTC::RPS6KB1 fusion in a poorly differentiated carcinoma with no other known drivers.
Findings
RNAseq identified a novel CLTC::RPS6KB1 fusion in the tumor.
No other known molecular drivers were detected in the tumor sample.
The tumor was a poorly differentiated carcinoma involving the lung and mediastinum.
Abstract
Cancer genetics studies have dramatically advanced the understanding of the molecular drivers in various types of neoplasms. This progress is also leading to the discovery of more new molecular agents to block those drivers, which has significantly improved cancer patient survival, especially in non-small cell lung cancer (NSCLC). However, in about 25% of NSCLC tumors molecular drivers are not yet known. Herein, we present a poorly differentiated carcinoma involving lung and mediastinum. Next generation sequencing-based RNAseq identified a novel fusion, CLTC::RPS6KB1, while no other known drivers were present.
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Taxonomy
TopicsCancer Genomics and Diagnostics · RNA modifications and cancer · Lung Cancer Treatments and Mutations