# A Novel CLTC::RPS6KB1 Fusion in a Poorly Differentiated Carcinoma Involving the Lung and Mediastinum

## TL;DR

A new gene fusion, CLTC::RPS6KB1, was found in a rare lung and mediastinum cancer with no known molecular drivers.

## Contribution

The discovery of a novel CLTC::RPS6KB1 fusion in a poorly differentiated carcinoma with no other known drivers.

## Key findings

- RNAseq identified a novel CLTC::RPS6KB1 fusion in the tumor.
- No other known molecular drivers were detected in the tumor sample.
- The tumor was a poorly differentiated carcinoma involving the lung and mediastinum.

## Abstract

Cancer genetics studies have dramatically advanced the understanding of the molecular drivers in various types of neoplasms. This progress is also leading to the discovery of more new molecular agents to block those drivers, which has significantly improved cancer patient survival, especially in non-small cell lung cancer (NSCLC). However, in about 25% of NSCLC tumors molecular drivers are not yet known. Herein, we present a poorly differentiated carcinoma involving lung and mediastinum. Next generation sequencing-based RNAseq identified a novel fusion, CLTC::RPS6KB1, while no other known drivers were present.