BAP1 complexes with YY1 and RBBP7 and its downstream targets in ccRCC cells
Ying Wu, Xue-Ying Li, Jin-Dong Chen, You-Fu Pan
TL;DR
This study explores how BAP1 interacts with other proteins and affects gene expression in kidney cancer cells.
Contribution
The study identifies BAP1's interacting proteins and gene expression changes in ccRCC cells.
Findings
BAP1 interacts with YY1 and RBBP7 in ccRCC cells.
BAP1 knockdown alters gene expression in 786-O cells.
Abstract
Clear cell renal cell carcinoma (ccRCC) is the most common type of kidney cancer. A few genes, such as BAP1, are associated with the tumorigenesis of ccRCC. Mutations in BAP1 are related to a proportion of ccRCCs. In this study, to explore the functional role of BAP1 in ccRCC, the potential interacting proteins with BAP1 in ccRCC cells are to be identified, and the gene expression profiles of BAP1 knockdown 786-O cells are to be analyzed.
Genes, proteins, chemicals, diseases, species, mutations and cell lines named across the full text — each resolved to its canonical identifier and authoritative record.
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Taxonomy
TopicsRenal and related cancers · Renal cell carcinoma treatment · Genetic and Kidney Cyst Diseases