# BAP1 complexes with YY1 and RBBP7 and its downstream targets in ccRCC cells

**Authors:** Ying Wu, Xue-Ying Li, Jin-Dong Chen, You-Fu Pan

PMC · DOI: 10.1515/biol-2025-1140 · 2025-07-18

## TL;DR

This study explores how BAP1 interacts with other proteins and affects gene expression in kidney cancer cells.

## Contribution

The study identifies BAP1's interacting proteins and gene expression changes in ccRCC cells.

## Key findings

- BAP1 interacts with YY1 and RBBP7 in ccRCC cells.
- BAP1 knockdown alters gene expression in 786-O cells.

## Abstract

Clear cell renal cell carcinoma (ccRCC) is the most common type of kidney cancer. A few genes, such as BAP1, are associated with the tumorigenesis of ccRCC. Mutations in BAP1 are related to a proportion of ccRCCs. In this study, to explore the functional role of BAP1 in ccRCC, the potential interacting proteins with BAP1 in ccRCC cells are to be identified, and the gene expression profiles of BAP1 knockdown 786-O cells are to be analyzed.

## Linked entities

- **Genes:** BAP1 (BRCA1 associated deubiquitinase 1) [NCBI Gene 8314], YY1 (YY1 transcription factor) [NCBI Gene 7528], RBBP7 (RB binding protein 7, chromatin remodeling factor) [NCBI Gene 5931]
- **Diseases:** clear cell renal cell carcinoma (MONDO:0005005), ccRCC (MONDO:0007763)

## Full-text entities

- **Genes:** RBBP7 (RB binding protein 7, chromatin remodeling factor) [NCBI Gene 5931] {aka RbAp46, SPGFX9}, YY1 (YY1 transcription factor) [NCBI Gene 7528] {aka DELTA, GADEVS, INO80S, NF-E1, UCRBP, YIN-YANG-1}, BAP1 (BRCA1 associated deubiquitinase 1) [NCBI Gene 8314] {aka HUCEP-13, KURIS, TPDS1, UBM2, UCHL2, UVM2}
- **Diseases:** kidney cancer (MESH:D007680), Clear cell renal cell carcinoma (MESH:D002292)
- **Cell lines:** 786-O — Homo sapiens (Human), Renal cell carcinoma, Cancer cell line (CVCL_1051)

## Figures

6 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12274967/full.md

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Source: https://tomesphere.com/paper/PMC12274967