Correction: Mutation in the rat interleukin 34 gene impacts macrophage development, homeostasis and inflammation
Stephen Huang, Omkar L Patkar, Sarah Schulze, Dylan Carter-Cusack, Susan Millard, Ginell Ranpura, Emma K Green, Emma Maxwell, Jeeva Kanesarajah, Gary Cowin, Damion Stimson, Nyoman D Kurniawan, Sahar Keshvari, Rachel Allavena, Allison R Pettit, Katharine M Irvine, David A Hume
TL;DR
This study corrects and expands on previous findings about a mutation in the rat IL34 gene and its effects on macrophage development and inflammation.
Contribution
The paper presents a novel IL34 loss-of-function model in rats to study its role alongside CSF1.
Findings
IL34 and CSF1 share overlapping functions in activating CSF1R in rats.
The mutation impacts macrophage development and inflammation in both the brain and periphery.
Abstract
Characterization of a novel IL34 loss-of-function model reveals overlapping functions of CSF1 and IL34 on CSF1R in the brain and periphery of the rat.
Genes, proteins, chemicals, diseases, species, mutations and cell lines named across the full text — each resolved to its canonical identifier and authoritative record.
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Taxonomy
TopicsIL-33, ST2, and ILC Pathways · Cytokine Signaling Pathways and Interactions
Article: Huang S, Patkar OL, Schulze S, Carter-Cusack D, Millard S, Ranpura G, Green EK, Maxwell E, Kanesarajah J, Cowin G, Stimson D, Kurniawan ND, Keshvari S, Allavena R, Pettit AR, Irvine KM, Hume DA (2025 June 18) Mutation in the rat interleukin 34 gene impacts macrophage development, homeostasis and inflammation. Life Sci Alliance 8(9): e202503264. doi: https://doi.org/10.26508/lsa.202503264. PMID: 40533345.
Following publication, the authors noticed that an old version of Supplementary Figure 2 (Figure S2) had been inadvertently included in this manuscript. The correct version of this figure has now replaced the older version.