# Correction: Mutation in the rat interleukin 34 gene impacts macrophage development, homeostasis and inflammation

**Authors:** Stephen Huang, Omkar L Patkar, Sarah Schulze, Dylan Carter-Cusack, Susan Millard, Ginell Ranpura, Emma K Green, Emma Maxwell, Jeeva Kanesarajah, Gary Cowin, Damion Stimson, Nyoman D Kurniawan, Sahar Keshvari, Rachel Allavena, Allison R Pettit, Katharine M Irvine, David A Hume

PMC · DOI: 10.26508/lsa.202503435 · Life Science Alliance · 2025-07-16

## TL;DR

This study corrects and expands on previous findings about a mutation in the rat IL34 gene and its effects on macrophage development and inflammation.

## Contribution

The paper presents a novel IL34 loss-of-function model in rats to study its role alongside CSF1.

## Key findings

- IL34 and CSF1 share overlapping functions in activating CSF1R in rats.
- The mutation impacts macrophage development and inflammation in both the brain and periphery.

## Abstract

Characterization of a novel IL34 loss-of-function model reveals overlapping functions of CSF1 and IL34 on CSF1R in the brain and periphery of the rat.

## Linked entities

- **Genes:** IL34 (interleukin 34) [NCBI Gene 146433], CSF1 (colony stimulating factor 1) [NCBI Gene 1435], CSF1R (colony stimulating factor 1 receptor) [NCBI Gene 1436]
- **Species:** Rattus norvegicus (taxon 10116)

## Full-text entities

- **Genes:** Il34 (interleukin 34) [NCBI Gene 498951]
- **Diseases:** inflammation (MESH:D007249)
- **Species:** Rattus norvegicus (brown rat, species) [taxon 10116]

## Full text

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## Figures

1 figure with captions in the complete paper: https://tomesphere.com/paper/PMC12267831/full.md

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Source: https://tomesphere.com/paper/PMC12267831