Additional Cover
Sandra Atlante, Luca Cis, Davide Pirolli, Michela Gottardi Zamperla, Veronica Barbi, Antonello Mai, Clemens Zwergel, Serena Marcozzi, Maria Elisa Giuliani, Giorgia Bigossi, Giovanni Lai, Fiorenza Orlando, Robertina Giacconi, Fabrizia Lattanzio, Giulia Matacchione
TL;DR
This paper introduces a xanthine derivative that inhibits a specific protein and has senolytic properties, which could help in treating age-related diseases.
Contribution
The study presents a novel xanthine derivative with dual action as an HSP90-alpha inhibitor and senolytic agent.
Findings
The compound shows strong inhibition of heat shock protein 90-alpha.
It exhibits senolytic activity, targeting and eliminating senescent cells.
Abstract
Cover legend: The cover image is based on the article A Xanthine Derivative With Novel Heat Shock Protein 90‐Alpha Inhibitory and Senolytic Properties by Sandra Atlante et al., https://doi.org/10.1111/acel.70047.
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Taxonomy
TopicsHeat shock proteins research · Calpain Protease Function and Regulation · Aldose Reductase and Taurine