# Additional Cover

**Authors:** Sandra Atlante, Luca Cis, Davide Pirolli, Michela Gottardi Zamperla, Veronica Barbi, Antonello Mai, Clemens Zwergel, Serena Marcozzi, Maria Elisa Giuliani, Giorgia Bigossi, Giovanni Lai, Fiorenza Orlando, Robertina Giacconi, Fabrizia Lattanzio, Giulia Matacchione, Chiara Giordani, Massimo Bracci, Fabiola Olivieri, Federico Boschi, Paola Tabarelli De Fatis, Giovanni Battista Ivaldi, Marco Malavolta, Antonella Farsetti, Maria Cristina De Rosa, Carlo Gaetano

PMC · DOI: 10.1111/acel.70171 · Aging Cell · 2025-07-16

## TL;DR

This paper introduces a xanthine derivative that inhibits a specific protein and has senolytic properties, which could help in treating age-related diseases.

## Contribution

The study presents a novel xanthine derivative with dual action as an HSP90-alpha inhibitor and senolytic agent.

## Key findings

- The compound shows strong inhibition of heat shock protein 90-alpha.
- It exhibits senolytic activity, targeting and eliminating senescent cells.

## Abstract

Cover legend: The cover image is based on the article A Xanthine Derivative With Novel Heat Shock Protein 90‐Alpha Inhibitory and Senolytic Properties
by Sandra Atlante et al., https://doi.org/10.1111/acel.70047.

## Figures

1 figure with captions in the complete paper: https://tomesphere.com/paper/PMC12266739/full.md

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Source: https://tomesphere.com/paper/PMC12266739