Research Progress and Challenges of Oligometastasis in Non-small Cell Lung Cancer

TL;DR

This paper reviews the current understanding and treatment of oligometastasis in non-small cell lung cancer, focusing on its unique biology and potential for cure.

Contribution

The paper provides a comprehensive overview of the definition, treatment advances, and challenges in NSCLC oligometastasis.

Findings

Oligometastasis represents a transitional state with limited tumor burden and distinct biological behavior.

Combination of systemic and local therapies offers potential for cure in selected patients.

Molecular targeted therapy and immunotherapy are transforming treatment approaches.

Abstract

寡转移是早期转移和广泛转移之间的过渡状态，肿瘤负荷有限，具备独特的肿瘤生物学行为。由于转移灶的数量和受累器官的数量相对有限，经过积极的系统治疗和局部巩固治疗，有潜在治愈的机会。随着分子靶向药物治疗和免疫治疗的飞速发展，非小细胞肺癌（non-small cell lung cancer, NSCLC）寡转移的综合治疗越来越受到重视。本文对NSCLC寡转移的定义、治疗进展以及存在的诸多挑战进行综述，以期为临床诊疗提供思路。