# Research Progress and Challenges of Oligometastasis in Non-small Cell Lung Cancer

**Authors:** Songzhen LI, Tianhang SHAO, Shuyang YAO

PMC · DOI: 10.3779/j.issn.1009-3419.2025.102.22 · 2025-06-30

## TL;DR

This paper reviews the current understanding and treatment of oligometastasis in non-small cell lung cancer, focusing on its unique biology and potential for cure.

## Contribution

The paper provides a comprehensive overview of the definition, treatment advances, and challenges in NSCLC oligometastasis.

## Key findings

- Oligometastasis represents a transitional state with limited tumor burden and distinct biological behavior.
- Combination of systemic and local therapies offers potential for cure in selected patients.
- Molecular targeted therapy and immunotherapy are transforming treatment approaches.

## Abstract

寡转移是早期转移和广泛转移之间的过渡状态，肿瘤负荷有限，具备独特的肿瘤生物学行为。由于转移灶的数量和受累器官的数量相对有限，经过积极的系统治疗和局部巩固治疗，有潜在治愈的机会。随着分子靶向药物治疗和免疫治疗的飞速发展，非小细胞肺癌（non-small cell lung cancer, NSCLC）寡转移的综合治疗越来越受到重视。本文对NSCLC寡转移的定义、治疗进展以及存在的诸多挑战进行综述，以期为临床诊疗提供思路。

## Linked entities

- **Diseases:** non-small cell lung cancer (MONDO:0005233)

## Full-text entities

- **Diseases:** NSCLC (MESH:D002289), metastasis (MESH:D009362), tumor (MESH:D009369)

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Source: https://tomesphere.com/paper/PMC12257161