Bacterial proteins encapsulate in extracellular membrane vesicles from Escherichia coli-infected macrophages
Risa Imamiya, Akinori Ninomiya, Hiroko Kato, Akari Shinohara, Yasuhiko Horiguchi, Mayuko Osada-Oka
TL;DR
This study shows that macrophages infected with E. coli release membrane vesicles containing bacterial proteins, which may contribute to inflammation.
Contribution
The study identifies specific E. coli proteins encapsulated in EVs from infected macrophages.
Findings
Sixty-three E. coli-derived proteins were detected in EVs from infected macrophages.
Both live and heat-inactivated E. coli triggered the release of EVs containing bacterial proteins.
Abstract
Extracellular membrane vesicles (EVs) are considered to be an inflammatory factor in several acute and chronic inflammatory diseases. We analyzed Escherichia coli-derived proteins in the EVs from macrophages that were infected with live and heat-inactivated Escherichia coli. Sixty-three proteins derived from live E. coli were detected in macrophage-derived EVs.
Genes, proteins, chemicals, diseases, species, mutations and cell lines named across the full text — each resolved to its canonical identifier and authoritative record.
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Taxonomy
TopicsExtracellular vesicles in disease · Bacterial Infections and Vaccines · Amyloidosis: Diagnosis, Treatment, Outcomes