# Bacterial proteins encapsulate in extracellular membrane vesicles from Escherichia coli-infected macrophages

## TL;DR

This study shows that macrophages infected with E. coli release membrane vesicles containing bacterial proteins, which may contribute to inflammation.

## Contribution

The study identifies specific E. coli proteins encapsulated in EVs from infected macrophages.

## Key findings

- Sixty-three E. coli-derived proteins were detected in EVs from infected macrophages.
- Both live and heat-inactivated E. coli triggered the release of EVs containing bacterial proteins.

## Abstract

Extracellular membrane vesicles (EVs) are considered to be an inflammatory factor in several acute and chronic inflammatory diseases. We analyzed Escherichia coli-derived proteins in the EVs from macrophages that were infected with live and heat-inactivated Escherichia coli. Sixty-three proteins derived from live E. coli were detected in macrophage-derived EVs.