The network approach to psychopathology: investigating inter-individual variability and the association with clinical relapse in psychosis
George Gillett, Dan W. Joyce, Cedric E. Ginestet, James H. MacCabe, Nicholas Meyer

TL;DR
This paper explores how interconnected symptoms in psychosis form networks and finds that these networks vary a lot between individuals and don't strongly predict relapse.
Contribution
The study reveals significant inter-individual variability in symptom networks and challenges assumptions about their association with clinical outcomes.
Findings
Substantial inter-individual variability in psychological symptom network structures was identified.
No strong evidence was found linking network structure to clinical relapse in psychosis.
Abstract
Recent years have seen a proliferation of interest in psychological networks, which conceptualise psychopathology as networks of inter-connected, mutually reinforcing symptoms. It has been hypothesised that the topological structure of such networks is associated with clinical presentation. Analysing data from a longitudinal study of participants diagnosed with psychosis, we identify substantial inter-individual variability in network structure, problematising causal inference from cross-sectional networks. Additionally, we do not find strong evidence for an association between network structure and clinical relapse.
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Taxonomy
TopicsMental Health Research Topics · Functional Brain Connectivity Studies · Tryptophan and brain disorders
