# The network approach to psychopathology: investigating inter-individual variability and the association with clinical relapse in psychosis

**Authors:** George Gillett, Dan W. Joyce, Cedric E. Ginestet, James H. MacCabe, Nicholas Meyer

PMC · DOI: 10.1038/s41537-025-00636-8 · 2025-07-03

## TL;DR

This paper explores how interconnected symptoms in psychosis form networks and finds that these networks vary a lot between individuals and don't strongly predict relapse.

## Contribution

The study reveals significant inter-individual variability in symptom networks and challenges assumptions about their association with clinical outcomes.

## Key findings

- Substantial inter-individual variability in psychological symptom network structures was identified.
- No strong evidence was found linking network structure to clinical relapse in psychosis.

## Abstract

Recent years have seen a proliferation of interest in psychological networks, which conceptualise psychopathology as networks of inter-connected, mutually reinforcing symptoms. It has been hypothesised that the topological structure of such networks is associated with clinical presentation. Analysing data from a longitudinal study of participants diagnosed with psychosis, we identify substantial inter-individual variability in network structure, problematising causal inference from cross-sectional networks. Additionally, we do not find strong evidence for an association between network structure and clinical relapse.

## Linked entities

- **Diseases:** psychosis (MONDO:0005485)

## Full-text entities

- **Diseases:** psychosis (MESH:D011618)

## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12229628/full.md

---
Source: https://tomesphere.com/paper/PMC12229628