Molecular docking analysis of bioactive molecules from herbs with snake venom phospholipase A2
Karthik Nagarajan S., Siva Annamalai, Bharath Christian C.B.S, Rajamaheswari K., Lavanya A., Arunachalam K.
TL;DR
This paper identifies plant-derived compounds that strongly inhibit snake venom phospholipase A2, suggesting potential herbal treatments.
Contribution
The study evaluates and identifies novel bioactive phytoconstituents as potent inhibitors of snake venom PLA2.
Findings
Gymnemic acid, Aristolochic acid, Lupeol, and Tocopherol show strong inhibitory potential against PLA2.
These compounds exhibit strong binding and molecular interactions with snake venom phospholipase A2.
Abstract
Snake venom, particularly phospholipase A2 (PLA2), exerts profound pathological effects, necessitating the development of potent therapeutic interventions. Therefore, it is of interest to the inhibitory potential of bioactive phytoconstituents from select medicinal herbs with PLA2. Analysis showed that Gymnemic acid, Aristolochic acid, Lupeol and Tocopherol are the best PLA2 inhibitors with strong binding and molecular interactions for further consideration.
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Taxonomy
TopicsVenomous Animal Envenomation and Studies · Bioactive Natural Diterpenoids Research · Nephrotoxicity and Medicinal Plants