Effect of autologous platelet concentrates on osteoblast cell activity during early osseointegration

TL;DR

This study compares different platelet concentrates to see which best supports bone cell activity for dental implants.

Contribution

The study identifies injectable-platelet-rich fibrin as the most effective for early osseointegration.

Findings

All tested platelet concentrates improved osteoblast adhesion, differentiation, and mineralization.

Injectable-platelet-rich fibrin showed the most significant calcium nodule formation.

Injectable-platelet-rich fibrin outperformed other types in promoting early osseointegration.

Abstract

Advances in implant dentistry focuses on enhancing the predictability of implant success using advanced regenerative techniques.
Autologous platelet concentrates rich in growth factors play a crucial role in stimulating osteoblast activity and improving
osseointegration at implant sites. Therefore, it is of interest to evaluate the osteogenic efficacy of four injectable platelet
concentrates: (1) injectable-platelet-rich fibrin, (2) leukocyte platelet-rich fibrin, (3) advanced platelet-rich fibrin and (4)
Advanced platelet-rich fibrin + on titanium surfaces. All tested concentrates enhanced osteoblastic adhesion, differentiation and
mineralization, with injectable-platelet-rich fibrin demonstrating the most significant calcium nodule formation. Thus, injectable-platelet-rich
fibrin proved to be the most effective in promoting early osseointegration compared to the other platelet-rich fibrin types.