# Effect of autologous platelet concentrates on osteoblast cell activity during early osseointegration

## TL;DR

This study compares different platelet concentrates to see which best supports bone cell activity for dental implants.

## Contribution

The study identifies injectable-platelet-rich fibrin as the most effective for early osseointegration.

## Key findings

- All tested platelet concentrates improved osteoblast adhesion, differentiation, and mineralization.
- Injectable-platelet-rich fibrin showed the most significant calcium nodule formation.
- Injectable-platelet-rich fibrin outperformed other types in promoting early osseointegration.

## Abstract

Advances in implant dentistry focuses on enhancing the predictability of implant success using advanced regenerative techniques.
Autologous platelet concentrates rich in growth factors play a crucial role in stimulating osteoblast activity and improving
osseointegration at implant sites. Therefore, it is of interest to evaluate the osteogenic efficacy of four injectable platelet
concentrates: (1) injectable-platelet-rich fibrin, (2) leukocyte platelet-rich fibrin, (3) advanced platelet-rich fibrin and (4)
Advanced platelet-rich fibrin + on titanium surfaces. All tested concentrates enhanced osteoblastic adhesion, differentiation and
mineralization, with injectable-platelet-rich fibrin demonstrating the most significant calcium nodule formation. Thus, injectable-platelet-rich
fibrin proved to be the most effective in promoting early osseointegration compared to the other platelet-rich fibrin types.