Recent advances in oxidative radical difunctionalization of N-arylacrylamides enabled by carbon radical reagents
Jiangfei Chen, Yi-Lin Qu, Ming Yuan, Xiang-Mei Wu, Heng-Pei Jiang, Ying Fu, Shengrong Guo
TL;DR
This paper reviews recent progress in using carbon radical reagents to functionalize N-arylacrylamides, enabling efficient synthesis of complex molecules.
Contribution
The paper highlights novel oxidative radical difunctionalization strategies for N-arylacrylamides using diverse activation methods.
Findings
Carbon radical reagents enable efficient difunctionalization of N-arylacrylamides.
Photonic, thermal, and electrochemical methods are effective for triggering these reactions.
This approach allows rapid construction of complex molecular structures.
Abstract
The field of radical-mediated functionalization of N-arylacrylamides has experienced considerable advancements in recent years, particularly in the domain of oxidative radical difunctionalization reactions employing carbon radical reagents. This approach provides a powerful and versatile strategy for the concurrent introduction of two distinct functional groups across the double bond of N-arylacrylamides, facilitating the rapid construction of complex molecular architectures. This review aims to summarize the diverse strategies for inducing intramolecular transformations of N-arylacrylamides using various carbon radical reagents, including methods initiated by photonic, thermal, or electrochemical processes, which have been extensively investigated by researchers.
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Taxonomy
TopicsRadical Photochemical Reactions · Catalytic C–H Functionalization Methods · Sulfur-Based Synthesis Techniques