# Recent advances in oxidative radical difunctionalization of N-arylacrylamides enabled by carbon radical reagents

## TL;DR

This paper reviews recent progress in using carbon radical reagents to functionalize N-arylacrylamides, enabling efficient synthesis of complex molecules.

## Contribution

The paper highlights novel oxidative radical difunctionalization strategies for N-arylacrylamides using diverse activation methods.

## Key findings

- Carbon radical reagents enable efficient difunctionalization of N-arylacrylamides.
- Photonic, thermal, and electrochemical methods are effective for triggering these reactions.
- This approach allows rapid construction of complex molecular structures.

## Abstract

The field of radical-mediated functionalization of N-arylacrylamides has experienced considerable advancements in recent years, particularly in the domain of oxidative radical difunctionalization reactions employing carbon radical reagents. This approach provides a powerful and versatile strategy for the concurrent introduction of two distinct functional groups across the double bond of N-arylacrylamides, facilitating the rapid construction of complex molecular architectures. This review aims to summarize the diverse strategies for inducing intramolecular transformations of N-arylacrylamides using various carbon radical reagents, including methods initiated by photonic, thermal, or electrochemical processes, which have been extensively investigated by researchers.