The diagnostic value of serum C-reactive protein/albumin and homocysteine/high-density lipoprotein-cholesterol in coronary microvascular angina pectoris

TL;DR

This study shows that combining two blood markers improves the accuracy of diagnosing coronary microvascular angina.

Contribution

The study introduces a novel diagnostic approach using combined blood markers for better detection of microvascular angina.

Findings

C-reactive protein/albumin and homocysteine/HDL-C are independent risk factors for microvascular angina.

Combining these markers improves diagnostic accuracy compared to using them individually.

Elevated levels of these markers are strongly associated with microvascular angina.

Abstract

The aim of this study was to investigate the correlation between the serum C-reactive protein/albumin ratio and homocysteine/high-density lipoprotein-cholesterol ratio with microvascular angina and assess their predictive value.

A total of 70 patients diagnosed with microvascular angina comprised the observation group, while 68 patients with normal or minimal (<50%) coronary stenosis and normal coronary blood flow formed the control group. Serum C-reactive protein, albumin, homocysteine, high-density lipoprotein-cholesterol, and other indexes were measured, and C-reactive protein/albumin and homocysteine/high-density lipoprotein-cholesterol ratios were calculated. Logistic regression, Pearson's correlation, and receiver operating characteristic analyses were conducted to identify independent risk factors for microvascular angina.

Significant differences in C-reactive protein, C-reactive protein/albumin, homocysteine, and homocysteine/high-density lipoprotein-cholesterol levels were found between the microvascular angina and control groups (p<0.05). Multivariate logistic regression analysis showed that C-reactive protein, C-reactive protein/albumin, homocysteine, and homocysteine/high-density lipoprotein-cholesterol were independent risk factors for microvascular angina, with the risk increasing alongside elevated C-reactive protein/albumin and homocysteine/high-density lipoprotein-cholesterol levels. The receiver operating characteristic analysis demonstrated that C-reactive protein/albumin, homocysteine/high-density lipoprotein-cholesterol, and their combined use were predictive of microvascular angina, with the combined area under the curve value exceeding that of individual markers.

Elevated C-reactive protein/albumin and homocysteine/high-density lipoprotein-cholesterol offer predictive value for microvascular angina diagnosis, with the combination providing superior diagnostic accuracy over individual indicators, supporting early microvascular angina identification.

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