# The diagnostic value of serum C-reactive protein/albumin and homocysteine/high-density lipoprotein-cholesterol in coronary microvascular angina pectoris

## TL;DR

This study shows that combining two blood markers improves the accuracy of diagnosing coronary microvascular angina.

## Contribution

The study introduces a novel diagnostic approach using combined blood markers for better detection of microvascular angina.

## Key findings

- C-reactive protein/albumin and homocysteine/HDL-C are independent risk factors for microvascular angina.
- Combining these markers improves diagnostic accuracy compared to using them individually.
- Elevated levels of these markers are strongly associated with microvascular angina.

## Abstract

The aim of this study was to investigate the correlation between the serum C-reactive protein/albumin ratio and homocysteine/high-density lipoprotein-cholesterol ratio with microvascular angina and assess their predictive value.

A total of 70 patients diagnosed with microvascular angina comprised the observation group, while 68 patients with normal or minimal (<50%) coronary stenosis and normal coronary blood flow formed the control group. Serum C-reactive protein, albumin, homocysteine, high-density lipoprotein-cholesterol, and other indexes were measured, and C-reactive protein/albumin and homocysteine/high-density lipoprotein-cholesterol ratios were calculated. Logistic regression, Pearson's correlation, and receiver operating characteristic analyses were conducted to identify independent risk factors for microvascular angina.

Significant differences in C-reactive protein, C-reactive protein/albumin, homocysteine, and homocysteine/high-density lipoprotein-cholesterol levels were found between the microvascular angina and control groups (p<0.05). Multivariate logistic regression analysis showed that C-reactive protein, C-reactive protein/albumin, homocysteine, and homocysteine/high-density lipoprotein-cholesterol were independent risk factors for microvascular angina, with the risk increasing alongside elevated C-reactive protein/albumin and homocysteine/high-density lipoprotein-cholesterol levels. The receiver operating characteristic analysis demonstrated that C-reactive protein/albumin, homocysteine/high-density lipoprotein-cholesterol, and their combined use were predictive of microvascular angina, with the combined area under the curve value exceeding that of individual markers.

Elevated C-reactive protein/albumin and homocysteine/high-density lipoprotein-cholesterol offer predictive value for microvascular angina diagnosis, with the combination providing superior diagnostic accuracy over individual indicators, supporting early microvascular angina identification.