Chitosan-Oligosaccharide-Bearing Biphasic Calcium Phosphate Bone Cement: Preparation and Angiogenic Activity In Vitro
Jianshen Liu, Xinghua Guo, Qishi Che, Zhengquan Su
TL;DR
Researchers improved bone cement by adding chitosan oligosaccharides, which helped promote blood vessel growth and could lead to better clinical applications.
Contribution
A novel drug-loaded bone cement with angiogenic properties was developed using chitosan oligosaccharides.
Findings
COSM-BCP bone cement particles showed a compressive strength of 29.58 MPa and 52.09% porosity.
COSM was released continuously in vitro and promoted angiogenesis.
The material demonstrated safety and potential for clinical use as a biological bone substitute.
Abstract
Although calcium phosphate bone cement has some advantages (it is easy to form, self-curing, and does not produce heat), some disadvantages remain that limit its clinical application. Therefore, the question of how we can modify CPC and further improve the various properties of calcium phosphate bone cement is a current research hotspot. In this paper, the preparation conditions and technology of biphasic calcium phosphate (BCP) were optimized; chitosan oligosaccharide (COSM) with MW ≤ 3000 Da was added to the optimal formulation of biphasic calcium phosphate cement particles, and its physical and chemical properties were characterized. The results showed that BCP bone cement carrier for clinical operations was successfully constructed by the high-temperature solid-state reaction method, and COSM-BCP bone cement particles were obtained by loading COSM drugs with an angiogenesis effect.…
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Taxonomy
TopicsBone Tissue Engineering Materials · Bone Metabolism and Diseases · Endodontics and Root Canal Treatments