Tropheryma whipplei Infections, Mexico, 2019–2021
Jesús Delgado-de la Mora, Peter Grube-Pagola, Christopher D. Paddock, Marlene DeLeon-Carnes, Alvaro C. Laga, Isaac H. Solomon, José María Remes-Troche, Jesús Javier Baquera-Heredia, Gabriel Quintero-Bustos, Juan Carlos León-Contreras, Arturo Ángeles-Ángeles
TL;DR
This paper reports two rare cases of Whipple’s disease caused by Tropheryma whipplei in Mexico between 2019 and 2021.
Contribution
It highlights the underdiagnosed presence of T. whipplei in Latin America and provides diagnostic confirmation methods.
Findings
Two confirmed cases of T. whipplei infection were identified in Mexico using advanced diagnostic techniques.
The disease remains underdiagnosed in Latin America due to lack of awareness among clinicians.
Multiple diagnostic methods were used to confirm the infection, including DNA sequencing of the 16S rRNA gene.
Abstract
Whipple’s disease is rarely diagnosed in Latin America. We describe 2 patients with Tropheryma whipplei infection diagnosed in Mexico during 2019–2021. Diagnoses were confirmed by histopathology, electron microscopy, immunohistochemistry, and DNA amplification and sequencing analysis of the 16S rRNA gene. Clinicians should be aware of T. whipplei infection and associated syndromes.
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Taxonomy
TopicsWhipple's Disease and Interleukins