# Tropheryma whipplei Infections, Mexico, 2019–2021

**Authors:** Jesús Delgado-de la Mora, Peter Grube-Pagola, Christopher D. Paddock, Marlene DeLeon-Carnes, Alvaro C. Laga, Isaac H. Solomon, José María Remes-Troche, Jesús Javier Baquera-Heredia, Gabriel Quintero-Bustos, Juan Carlos León-Contreras, Arturo Ángeles-Ángeles, Braulio Martínez-Benítez

PMC · DOI: 10.3201/eid3105.241046 · 2025-05-01

## TL;DR

This paper reports two rare cases of Whipple’s disease caused by Tropheryma whipplei in Mexico between 2019 and 2021.

## Contribution

It highlights the underdiagnosed presence of T. whipplei in Latin America and provides diagnostic confirmation methods.

## Key findings

- Two confirmed cases of T. whipplei infection were identified in Mexico using advanced diagnostic techniques.
- The disease remains underdiagnosed in Latin America due to lack of awareness among clinicians.
- Multiple diagnostic methods were used to confirm the infection, including DNA sequencing of the 16S rRNA gene.

## Abstract

Whipple’s disease is rarely diagnosed in Latin America. We describe 2 patients with Tropheryma whipplei infection diagnosed in Mexico during 2019–2021. Diagnoses were confirmed by histopathology, electron microscopy, immunohistochemistry, and DNA amplification and sequencing analysis of the 16S rRNA gene. Clinicians should be aware of T. whipplei infection and associated syndromes.

## Linked entities

- **Diseases:** Whipple’s disease (MONDO:0005116)
- **Species:** Tropheryma whipplei (taxon 2039)

## Full-text entities

- **Diseases:** T. whipplei infection (MESH:D007239), Whipple's disease (MESH:D008061)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12044244/full.md

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Source: https://tomesphere.com/paper/PMC12044244